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22. Viral Hepatitis - Alphabet Soup Viral Hepatitis What...

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3/5/2009 1 Viral Hepatitis What every pharmacist needs to know… Alphabet Soup • A • B • C • D • E What do we have against the letter F? • G What I’m not going to talk about… • A • E - Acute liver disease - No chronic form - Most importantly - no treatment, no drugs! • D - need to have B first • F - doesn’t exist (yet) • G - doesn’t cause liver disease That leaves… Hepatitis B - HBV • Hepatitis C HCV Hepatitis C - HCV Both chronically infect the liver and called hepatitis but that’s about where the similarity ends Hep B vs Hep C HBV HCV - partially DS DNA virus - 3.2 kb - 4 genes - 5 proteins - + sense enveloped ss RNA virus - 1 polyprotein - Cleaved to 3 structural and 7 NS proteins Outline • HBV – The virus – The problem - public health The problem public health – The disease - natural history – The treatment • HCV – Ditto….
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