24 Fungi 2 - Systemic Mycosis True Pathogens Blastomyces dermatitidis Coccidoides immitis Histoplasma capsulatum Paracoccidioides brasiliensis are

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3/24/2010 1 Systemic Mycosis ( The Fungus among us ) Systemic Mycosis True Pathogens: Blastomyces dermatitidis Coccidoides immitis Histoplasma capsulatum Paracoccidioides brasiliensis – are able to infect healthy individuals Systemic mycosis • Spores are inhaled into the lungs, germinate, invade and destroy other organs and tissue • In healthy individuals they cause mild and self-limiting infections • Can be fatal in immuno-compromised patients Coccidioidomycosis • Usually caused by Coccidioides immitis • Most cases are along the USA/Mexico border (San Joaquin Valley Fever) • Fungus grows in soil, produces spores, wind carries spores (1/3 of population is infected) • Spores are inhaled Coccidioidomycosis • Spores germinate in the lung and form spherules (20-40um) filled with endospores • Spherules rupture and release endospores, each of which can lead to a new spherule • Can spread to bone, skin, GI, GU in 0.5% of cases • Can cause meningitis if they infect the CNS • Diagnosis: skin test, serology, culture, direct examination Histoplasmosis • Usually caused by Histoplasma capsulatum • Fungus grows in the soil and produces conidia which are spread by the wind • When inhaled they germinate into yeast-like cells which multiple within macrophages • Infections can present as benign (90%) -> self-limiting ->chronic ->progressive -> fatal
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This note was uploaded on 05/09/2010 for the course LMP 232 taught by Professor Crandall during the Spring '10 term at University of Toronto- Toronto.

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24 Fungi 2 - Systemic Mycosis True Pathogens Blastomyces dermatitidis Coccidoides immitis Histoplasma capsulatum Paracoccidioides brasiliensis are

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