Unformatted text preview: This reaction is, however, ineffective for preparation of primary alkyl halides. Discuss the reason behind this, with reference to the operative reaction mechanism and using curved arrows to represent electron flow. How might a primary alkyl chloride be prepared from a primary alcohol? 2. Grignard reagents (R-MgX) are exceptionally useful in organic synthesis, as seen in detail in Chapter 17. They do have limitations, however. Explain, with the use of a reaction mechanism (including curved arrows) why a Grignard reagent (e.g. ethylmagnesium bromide) is unstable in an alcohol solvent such as ethanol. Why can’t Grignard reagents generally be prepared from alkyl fluorides? OH HCl ether Cl...
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- Spring '10
- Organic chemistry, Diethyl ether, Ether, tertiary alkyl chloride, J. McMurry