chap19b - HYDROLYSIS REACTIONS HYDROLYSIS Hydrolysis of...

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HYDROLYSIS REACTIONS HYDROLYSIS REACTIONS
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O C R O R O C R O + OH _ + R O H O C R O R O C R OH + + R O H H 2 O H 2 SO 4 Hydrolysis of Esters Hydrolysis of Esters Basic Solution Acidic Solution excess heat heat Hydrolysis requires strong acid or base and heating under reflux. ….. It’s not easy ! Na + Na +
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: .. .. .. _ : .. O C R O R' H O : : .. .. O C R O R' O H .. _ .. : slow : : .. .. O C R O R' O H .. _ .. : : : .. .. O C R O R' O H .. _ .. : : : .. O C R O R' O H .. _ .. : : : O C R O H .. : O R' : + .. .. R C O O .. : .. _ O R' H + .. .. .. _ .. Hydrolysis of an Ester in Base Hydrolysis of an Ester in Base proton transfers H-OH HO - NaOH
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: .. .. .. .. O C R O R' H H O H : .. .. O C R O R' O H H H .. .. slow .. .. O C R O R' O H H H .. .. .. .. O C R O R' O H H H .. .. .. O C R O R' O H H H .. .. : + : .. O C R O R' O H H H .. .. : + : .. O C R O H H .. : O R' H : + + + : : : + + + : O C R O H .. .. .. Hydrolysis of an Ester in Acid Hydrolysis of an Ester in Acid proton transfers H 3 O + + H 3 O + H-OH 2 + OH 2 H 2 SO 4 / H 2 O
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C R NH 2 O C R O + OH _ + O C R NH 2 O C R OH + + H 2 O H 2 SO 4 NH 3 (NH 4 )SO 4 Hydrolysis of Amides Hydrolysis of Amides Basic Solution Acidic Solution excess heat heat Hydrolysis requires strong acid or base and heating under reflux. ….. It’s not easy !
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This note was uploaded on 05/11/2010 for the course FD SC 210 taught by Professor Liu,r./orta-ramirez during the Spring '10 term at Cornell University (Engineering School).

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chap19b - HYDROLYSIS REACTIONS HYDROLYSIS Hydrolysis of...

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