lecture 17

lecture 17 - Lecture 17 Chapter 11 Soilborne and...

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1 Lecture 17 Chapter 11 Soilborne and Arthropodborne Diseases A. Soilborne Bacterial Diseases 1. Anthrax 2. Tetanus 3. Gas Gangrene 4. Leptospirosis B. Arthropodborne Bacterial Disease 1. Bubonic Plague 2. Tularemia 3. Lyme Disease 4. Relapsing fever . (Chapter 11) Arthropodborne Bacterial Disease C. Rickettsial Arthropodborne Diseases Rocky Mountain spotted fever Epidemic typhus (typhus fever) Endemic typhus Other rickettsial diseases. Soilborne Bacterial Diseases Headaches, muscular aches, fever, kidney failure Leptospirosis Leptospira interrogans Endospores contaminated open wound; toxins destroys adjacent tissue. Gas gangrene Clostridium perfringens Toxin causes uncontrolled muscle contraction. Tetanus Clostridium tetani 3 forms: Cutaneous, Inhalation, Gastrointestinal. Easily septicemic and proliferates in blood. Anthrax Bacillus anthracis Characteristics Disease Pathogen Anthrax Agent: Bacillus anthracis (first identified by Robert Koch) Aerobic, endospore-forming Gram + long rods. Reservoir: Spores found in contaminated soil usually ingested by grazing animals. Spores can survive in soil for several decades. Infected animal carcasses are infective. Anthrax Transmission: Humans (accidental hosts) are infected by handling infected animal hair, skin, or wastes. Pathogenicity A. Cutaneous anthrax B. Inhalation Anthrax (Woolsorter’s Disease) C. Gastrointestinal Anthrax Cutaneous Anthrax One endospore in a skin abrasion can start disease, Spores geminate, vegetative cell multiple • Symptoms: Skin infection begins as a raised itchy bump that resembles an insect bite but within 1-2 days develops into a vesicle and then a painless ulcer, usually 1-3 cm in diameter, with a characteristic black necrotic (dying) area in the center. Lymph glands in the adjacent area may swell.
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2 Cutaneous Anthrax From the necrotic ulcer the infection may disseminate into the blood steam giving rise to septicemia . 5 –20 % untreated patients develop septicemia which is frequently fatal. Cutaneous Anthrax continued About 20% of untreated cases of cutaneous anthrax will result in death. Antibiotic treatment is usually penicillin. Inhalation Anthrax Inhalation Anthrax Transmission: Humans may become infected by the inhalation of the endospores. (Now use as biological warfare to threatens mass infection.) However, thousands of spores have to be inhaled before a person becomes ill. Inhalation anthrax • Initial symptoms may resemble a common flu/cold. • After several days, the symptoms may progress to severe breathing problems and shock. • After onset of respiratory distress, death
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This note was uploaded on 05/11/2010 for the course BIOL 1011 taught by Professor Gayda,r during the Spring '08 term at LSU.

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lecture 17 - Lecture 17 Chapter 11 Soilborne and...

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