Lecture15-6 - Lecture 15 B Diseases of the Lower...

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1 Lecture 15 B. Diseases of the Lower Respiratory Tract 1. Tuberculosis 2. Pneumonias (typical and atypical) 3. Legionnares’ disease 4. Q fever 5. Psittacosis and Chlamydial Pneumonia Chapter 10 – Foodborne and Waterborne Infections A. Foodborne and Waterborne Intoxications. 1. Botulism 2. Staphylococcal food poisoning 3. Clostridial food poisoning 4. Bacillus cereus food poisoning B. Foodborne and Waterborne Infections 1. Typhoid fever 2. Salmonellosis 3. Shigellosis 4. Cholera 5. E. coli diarrheas 6. Others: Ulcers, Camplyobacteriosis, Listeriosis, Brucellosis, and more. Tuberculosis Agent: Mycobacterium tuberculosis acid fast positive, rod-shaped bacteria with a waxy, mycolic acid , cell wall that is resistant to drying and disinfectants. Formation of a tubercle . 1. Mycobacterium tuberculosis is inhaled to the lungs. 2. Bacilli enters the alveolus 3. The bacilli multiply within macrophages. 4. Body’s immune system dispatches other macrophages. 5. Wall off infected cells – forms tubercle . (note: bacteria are not killed) Multi-drug resistant tuberculosis (MRTB) TB strains resistant to two or more drugs, some cases to all known antibiotics. – Concentrated in the AIDS populations in U.S. – Associated higher than normal death. World: MRTB hotspots found in Estonia, Latvia, Russia, China, India, Iran, Romania, South American and Africa. (>3% cases had MRTB). Why?– Primarily because unsupervised patients stopped taking their medication prematurely . Tuberculosis continued • Immunization—BCG vaccine Current vaccine is injection of an attenuated (weakened) strain of Mycobacterium bovis . Gives tuberculosis in cows . Strain called bacille Calmette Guerin or BCG After Albert Calmette and Camille Guerin two french investigors who developed it in the 1920s. Not approved in the United States. Tuberculosis Worldwide
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2 Microbial Diseases of Lower Respiratory System Compromised patients G - pneumonia Haemophilus influenze Klebsiella pneumoniae Serratia marcescens Hospital acquired infection G+ pneumonia Staphylococcus aureus Occurs in parrot and parrot like birds Psittacosis Chlamydia psittaci Rickettsia, Occurs dairy cows found in raw milk Q fever Coxiella burnetii Spread by aerosols Legionellosis Legionella pneumophila Primary atypical pneumonia "walking pneumonia" Mycoplasma pneumoniae Chlamydial pneumonia Chlamydia pneumoniae Rust-colored sputum Pneumococcal pneumonia Streptococcus pneumoniae Term- fluid build-up in lungs. Pneumonia Chronic lung disease characterized by low-grade fever, and destruction of lung tissue Tuberculosis (Consumption) Mycobacterium tuberculosis Characteristics Disease Pathogen Terms Describing Lower Respiratory Infections bronchitis or bronchiolities - infection affecting the bronchi pneumonia - general descriptive term which refers to the presence of fluid build- up in the lungs. Bacterial Pneumonias
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Lecture15-6 - Lecture 15 B Diseases of the Lower...

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