Unformatted text preview: Types of Variation Announcements:
s Problem Set # 1 due February 22nd turn in at beginning of lecture. Due Mon. March 1 s Problem Set #2: s Field trip assignment posted on elms.
x Look it over to see if you have ?s.
3 Due by May 7th
th s Types of Variation
Genotypes, Phenotypes and Evolution s Complete Dominance
x Caused by autosomal dominant allele
3E.g. Polydactyly xChildren with only one parent with trait have 50% chance.
Penetrance = frequency expressed Types of Variation
Genotypes, Phenotypes s Complete Dominance xE.g. Achondroplasia
3What is the chance of having a child of average height if two people with Achondroplasia marry? Aa x Aa = 25% aa; 50% Aa 25% AA (lethal) s Autosomal Dominant:
x Huntington's disease s 1 in 20,000 Duplication on chromosome #4 (CAG) s Autosomal Recessive: CF gene on chromo # 7
x Most common lethal genetic disease among caucasians in US
3 1:2500 births 3 1:20 carriers s Autosomal Recessive: Tay-Sachs s Chromosome # 5 mutation s High among U.S. Jewish population s O...
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- Spring '10
- Genetics, achondroplasia, Recessive genetic disorders, X-linked recessive Genetic