lecture0203final - Backbone of bacteriorhodopsin shows 7...

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Backbone of bacteriorhodopsin shows 7  membrane-spanning alpha-helices with  largely hydrophobic R-groups 
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Backbone of myoglobin shows largely  polar residues exposed to the  surrounding solution
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Domains in the Tertiary Structure Domains – structural units within  the proteins’ sequence Domains can be described  according their distinctive  structure   Alpha helical Beta-sheet Random coil Or their  function: A catalytic domain  A ligand-binding domain
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Figure 2.32 Beta sheet and helical domains of a ribonuclease Note use of disulfide bridges to increase stability
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Motifs Defined arrangements of different  domains. e.g. coiled – coil motif in myosin and  other cytoskeletal proteins – forms  rigid rods 
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Motifs – e.g.  The alpha-beta barrel of the enzyme  triose-phosphate isomerase found in 10% of all enzymes
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Motifs – e.g.  The 7 transmembrane-domain  family of G-protein-coupled receptor  proteins. 
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As with domains, motifs can be  defined according to their  function. “ligand-binding motif”
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lecture0203final - Backbone of bacteriorhodopsin shows 7...

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