Lecture 1

Lecture 1 - Lecture 1 Biomolecules List of biomolecules in...

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Lecture 1 Biomolecules List of biomolecules in E. coli (% by weight; variety—no. of types) H 2 O (70; 1) ions (1; ~20) Monomers amino acids (0.4; 20[120]) sugars (3; ~200) nucleotides (0.4; 5[~200]) lipids (2; 50) “secondary” compounds (0.2; 250) Polymers proteins (15; 2000-3000) polysaccharides (included with monos) nucleic acids (RNA: 6; 1000; DNA: 1;1) membranes (included with monos) various (lignins, isoprenoids) combinations: glycolipids, lipoproteins, etc. Characteristics 3-D structures: handedness (chirality), (polymers:) sense: directionality Forces that hold molecules together covalent: strong (142 –O:O- to 946 N:::N, -C:C- 343 kJ/mol)(Fig 1.6) hydrogen: 12-30 kJ/mol (Tab 1.3) ionic: 20 kJ/mol Vanderwaal’s: 0.4-4.0 kJ/mol hydrophobic: <40 kJ/mol Weak forces Stability and flexibility: 3-D structures Structural complementarity, recognition, complexes (especially Vanderwaal’s~ 1/r 3 to 1/r 6 ) Limited environmental tolerance Energy implied in any changes in the forces/bonds holding molecules together:
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Lecture 1 - Lecture 1 Biomolecules List of biomolecules in...

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