This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: 2 group to amine R NHR' O 1. LiAlH 4 2. H 3 O + R NHR' Reduction of amides KH or KOH R Br R CN R Reduction of nitriles to form primary amines 2. H 2 O NH 2 O H H O O NHR Mannich Reaction 1. LiAlH 4 ! RNH 2 K + RNH 2 NaCN Related to reductive amination but with no reducing agent Other concepts to review 1. Simple nomenclature 2. Basicity factors affecting basicity, aromaticity, aliphatic vs aromatic amines, substituent effect, resonance, inductive effects...
View Full Document
This note was uploaded on 05/13/2010 for the course CHEM ORGANIC CH taught by Professor Dotsevisogah during the Spring '09 term at Cornell University (Engineering School).
- Spring '09