Chapter_43

Chapter_43 - Chapter 43 Defense Against Disease: The Immune...

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Unformatted text preview: Chapter 43 Defense Against Disease: The Immune System Three lines of defense against microbial attack See Fig 43.2 Innate defenses Acquired immunity Three lines of defense: 1: external barriers (skin, mucous membranes) Three lines of defense: A. skin Three lines of defense: external barriers A.skin physical barrier to microbial entry Three lines of defense: 1. external barriers A.skin physical barrier inhospitable environment for growth; dry, dead cells at surface. Sweat/sebaceous glands secreting acids & natural antibiotics like lactic acid. Three lines of defense: 1. external barriers A.skin physical barrier inhospitable environment B.mucous membranes of respiratory and digestive tracts well-defined. Secretions have antibacterial enzymes. Dirt caught in mucus, moved by cilia Three lines of defense: 1. external barriers A.skin physical barrier inhospitable environment B.mucous membranes C.Stomach; if microbes swallowed, acids and protein-digesting enzymes destroy them Lines of defense: 2. nonspecific internal defense Lines of defense: 2. nonspecific internal defense A.phagocytic cells: white blood cells (WBC) in extracellular fluid, amoeboid shape, destroy microbes by phagocytosis. See Fig 43.1 Fig. 43-3 Microbes PHAGOCYTIC CELL Vacuole Lysosome containing enzymes Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells: WBC that destroy body cells infected by viruses and cancerous cells by punching HOLES in them. Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells C. inflammatory response, caused by large-scale microbial invasion through wound Fig. 43-6 EXTRACELLULAR FLUID Lipopolysaccharide Flagellin TLR4 TLR5 Helper protein TLR9 TLR3 WHITE BLOOD CELL VESICLE CpG DNA ds RNA Inflammatory responses Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells C. inflammatory response histamine released by damaged cells Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells C. inflammatory response histamine increased blood flow washes out wound Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells C. inflammatory response histamine increased blood flow inflammation (red, swollen, warm) Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells C. inflammatory response histamine increased blood flow inflammation other chemicals attract Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells C. inflammatory response histamine increased blood flow inflammation other chemicals macrophages (WBC engulf bacteria, dirt, tissue debris) Lines of defense: 2. nonspecific internal defense A. phagocytic cells B. natural killer cells C. inflammatory response histamine increased blood flow inflammation other chemicals macrophages blood clotting walls off wounded area....
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This note was uploaded on 05/13/2010 for the course BIOL 1202 taught by Professor Gregg during the Spring '08 term at LSU.

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Chapter_43 - Chapter 43 Defense Against Disease: The Immune...

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