Insulin and leptin

Insulin and leptin - Endocrine Communication: Type II...

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Hormones: Broadcasting Chemical Signals Endocrine System: glands, hormones, target cells Hormones: peptides, amino acids, steroids Modes of Signal Transduction antagonistic control, multiple effectors, common effect Case Study: Intersecting Pathways: Leptin, Ghrelin, Insulin, and Glucacon Insulin- glucose uptake Glucagon- Glucose release Ghrelin- Got the munchies? Leptin- Talking Fat How do these pathways intersect? Endocrine Communication: Type II Diabetes Case Study
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Forms of Physiologic Communication Hormone Signaling Nerve Signaling Signal Released from cell Diffused into bloodstream Wide Ranging effect Slow Long lasting Signal transmitted within cell Defined pathways More specific effects Fast Shorter Duration
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Endocrine Glands & Homeostasis
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Types of Hormones Insulin 51 amino acids long
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Receptor = Transcription Factors => Gene Expression Signal Transduction Pathways G-proteins -> ‘2 nd Messengers’ (Ca +2 , cAMP) => Activate Enzymes Hormones use Receptors & Signal Transduction
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Insulin and Glucagon: an Antagonist Pair of Hormones Glucagon triggers conversion of Glycogen into Glucose
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Hormonal Regulators of Appetite (not an exhaustive list)
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One Genetic Cause of Obesity Leptin (or Leptin receptor) deficient Mice
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Insulin and leptin - Endocrine Communication: Type II...

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