Lecture7_'10Student

Lecture7_'10Student - Promoter Transcripon iniaon complex...

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Regula’ng Gene Expression What do cells do with DNA?
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How do we get a paw like this? Or Hand? Lettice L A et al. PNAS 2002;99:7548-7553
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Diferent cells, Diferent Func’ons Neutrophil in ac/on Bea/ng cardiac muscle cells derived from diFeren/a/on of stem cell line Neuronal path±nding--op/c tectum hBp://www.neurofly.com/neuro±io_²les/large.mov
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5’ 5’ 3’ 3’ 3’ 5’ H 2 N H 2 N COOH COOH AMINO ACID SEQUENCE FUNCTIONAL PROTEINS RNA DNA The “Central Dogma” R. Grunwald
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Is DNA available for Tx?
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Histone Acetylation + DNA Methylation -
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Transcrip’on Ini’a’on
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Unformatted text preview: Promoter Transcripon iniaon complex Regulatory or control elements Enhancers Acvators and repressors 5 5 3 3 3 5 H 2 N H 2 N COOH COOH AMINO ACID SEQUENCE FUNCTIONAL PROTEINS RNA DNA The Central Dogma R. Grunwald Gene: 1 copy mRNA: many copies (10 2-10 4 ) Proteins: Many, many copies (10 4- 10 7 ) Gene Expression: Transcription, Translation, & Amplification Protein Function (enzymes, transporters, structures, regulators) Structure-funcon relaonships mRNA expression How do we get a paw like this? Sources Fly wing image: hBp://hietakangaslab.110mb.com/index.php?slab=research...
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Lecture7_'10Student - Promoter Transcripon iniaon complex...

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