TMcoupling reactions

TMcoupling reactions - of different products from all of...

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Heck Reaction The palladium-catalyzed C-C coupling between aryl halides or vinyl halides and activated alkenes in the presence of a base is referred as the "Heck Reaction". Recent developments in the catalysts and reaction conditions have resulted in a much broader range of donors and acceptors being amenable to the Heck Reaction. One of the benefits of the Heck Reaction is its outstanding trans selectivity. Mechanism:
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Stille Reaction: Stille Coupling The Stille Coupling is a versatile C-C bond forming reaction between stannanes and halides or pseudohalides, with very few limitations on the R-groups. Well-elaborated methods allow the preparation
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Unformatted text preview: of different products from all of the combinations of halides and stannanes depicted below. The main drawback is the toxicity of the tin compounds used, and their low polarity, which makes them poorly soluble in water. Stannanes are stable, but boronic acids and their derivatives undergo much the same chemistry in what is known as the Suzuki Coupling. Improvements in the Suzuki Coupling may soon lead to the same versatility without the drawbacks of using tin compounds. Suzuki Coupling Suzuki Coupling Mechanism...
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This note was uploaded on 05/13/2010 for the course CHEM 152L taught by Professor Baldwin during the Summer '09 term at Duke.

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TMcoupling reactions - of different products from all of...

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