overhead3rr_607 AUG-08

overhead3rr_607 AUG-08 - 3 BIOLOGICAL BASIS OF PSYCHOACTIVE...

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3. BIOLOGICAL BASIS OF PSYCHOACTIVE DRUG USE: PART II 3.1 Receptors Genes and Proteins Dopamine ‘D2’ receptors Relation to schizophrenia and addiction Individual differences in perceived ‘high’ Up-regulation/down-regulation, super-sensitivity Treatment effects and side effects of anti-psychotic medications Down-regulation of D2 receptors, and ‘positive’symptoms Down-regulation and ‘tardive dyskinesia’ 3.2 Acute effects of psychoactive drugs Direction of Action: Agonists vs. Antagonists Agonist = a drug that acts to increase the natural effects of a neurotransmitter Antagonist = a drug that acts to decrease the natural effects of a neurotransmitter 1
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Mechanisms of Action: Direct vs. Indirect If a drug (either agonist or antagonist) exerts its effect by binding to the receptors for a neurotransmitter, it is described as having a “direct” mechanism of action. If a drug (either agonist or antagonist) exerts its effect by some means other than binding to the receptors for a
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