overhead2rr_607-2001 - Olds and Milner: motivation vs....

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2. Biological Basis of Psychoactive Drug Use: Part I 2.1 Basic physiology of the central nervous system (CNS) Hierarchical organization Evolutionary development of CNS (phylogenetic parallels) Blood-brain barrier (adaptive function) Learning, nerve cell connections, and CNS i growthi 2.2 The brain: regions involved in psychoactive drug effects Phylogenetic breakdown of the brain (hind, mid, fore) Predictors of drug effect: lipid/water solubility Focal vs. diffuse effects Phylogenetic recency and drug-dose sensitivity 2.3 Overview of the limbic system A region specialized to regulate adaptive behaviour 4 drives; Drug Use as possible “5 th Drive” Two critical sets of processes: Emotions and motivation Negative feedback: a model of consumption behaviour Addiction, craving, and satiety Limbic Structures: Ascending Dopamine System
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Unformatted text preview: Olds and Milner: motivation vs. reinforcement Parallel to Cocaine Positive feedback - Dopamine: More glue than glee? 1 2.4 The structures and functions of the neuron Diagram, labels, and definitions of neuronal structures 2.5 Communication between neurons (neurotransmission) Vesicles Synapse Excitatory and inhibitory post-synaptic potentials Receptors: The critical substrate for drug effects Enzymes and re-uptake transporters 2.7 Neurotransmitters: definition, criteria, examples First transmitter discovered: Acetylcholine Key transmitters related to psychopathology & addictions 1/ Monoamines: Dopamine Norepinephrine Serotonin 2/Amino Acid transmitters: Endogenous opioids (Endorphins) GABA (brains dimmer switch) Glutamate (relation to MSG) 2...
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overhead2rr_607-2001 - Olds and Milner: motivation vs....

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