326Mretro - Human Retroviruses-HIV Enveloped (+) ssRNA with...

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Human Retroviruses-HIV Enveloped (+) ssRNA with reverse transcriptase (RT) Genome (+) ssRNA (dimer) HIV has tropism for TH and macrophages Encounter- blood and some body fluids (semen, vaginal secretions, etc.) carry the virus; it can be spread horizontally by unprotected sex and sharing of IV needles or contaminated blood supply; genital ulcer disease (Herpes, syphilis) can enhance transmission; also spread vertically from mother to fetus Entry and multiplication HIV via its specific surface glycoprotein (gp 120) is adsorbed into CD4 (TH) cell and endocytosed The dimeric RNAs are uncoated and RT synthesizes a single cDNA The cDNA is used to make dsDNA which goes to TH nucleus and is integrated into host genome as provirus (latent) Latency ends when the provirus genes are transcribed Viral mRNA translated in cytoplasm and viruses are assembled in cytoplasm near plasma membrane Nucleocapsids bud thru the plasma membrane and pick up envelopes containing both host and viral proteins
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This note was uploaded on 05/15/2010 for the course BIO 326M taught by Professor Field during the Spring '08 term at University of Texas at Austin.

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326Mretro - Human Retroviruses-HIV Enveloped (+) ssRNA with...

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