Discussion session 5 97-2003 version

Discussion session 5 97-2003 version - Discussion session...

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Discussion session 5: 2. What are cytokines, monokines, lymphokines and chemokines? 3. What are interleukins and what are the major functions of interleukins? 4. Which cells express MHC I and MHC II? How are these involved in clearing pathogens from the host? 5. What is Humoral immunity and Cell mediated immunity? 6. What are the two major types of T cells? Describe their function/mode of action. 7. What is TCR? How is it involved in T cell activation? 8. What does CD stand for? What do CD4 and CD8 do? 9. List 3 mechanisms of killing utilized by cytotoxic T cells. 10.Compare and contrast the antigen mediated and the superantigen mediated T cell activation. 11.What are the three main functions of B cells?
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12.What is the difference between T independent Antigen and T dependent antigen? 13.What are the functions of memory and plasma B cells. 14.What is diversity and specificity in T cells? Remember: MHC I and MHC II are proteins and NOT cells. They are expressed on the surface of cells. The APCs or the Antigen presenting cells are B cells, dendritic cells and macrophages 1. Two major modes of Antigen presentation: EXOGENOUS and ENDOGENOUS EXOGENOUS: -Exogenous or Ag present externally is ingested by endocytosis or phagocytosis
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lysosome -Ag is degraded into small peptides which are then presented with class II MHC molecules on the membrane of the APC ENDOGENOUS: -Endogenous Ag which is produced within the cell itself (virus infected cell) -Ag is degraded within the cytoplasm into peptides. In the ER, Ag binds to Class I MHC -Peptide-MHC I complex then move to the cell surface 2. CYTOKINES: Cyto-cell and kine-movement. Category of signaling molecules that are used
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This note was uploaded on 05/15/2010 for the course BIO 326M taught by Professor Field during the Spring '08 term at University of Texas at Austin.

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Discussion session 5 97-2003 version - Discussion session...

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