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Unformatted text preview: Different cellular membranes vary in lipid composition. Phospholipids and sphingolipids are asymmetrically distributed in the two leaflets of the bilayer, whereas cholesterol is fairly evenly distributed in both leaflets. Natural biomembranes generally have a fluid-like consistency. In general, membrane fluidity is decreased by sphingolipids and cholesterol and increased by phosphoglycerides. The lipid composition of a membrane also influences its thickness and curvature. Lipid rafts are microdomains containing cholesterol, sphingolipids, and certain membrane proteins that form in the plane of the bilayer. These aggregates are sites for signaling across the plasma membrane. *From: Molecular Cell Biology , Lodish, et al. W. H. Freeman & Co. 2003...
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- Spring '09