BIS 104 Mukouyama Fig 3 spring 2010

BIS 104 Mukouyama Fig 3 spring 2010 - SMC differentiation,...

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Mukouyama et al., summary of results depicted in Fighre 3, page 696. Results presented in Figure 2 showed that when successive developmental embryo stages(E13.5, 14.5, 15.5) where immunostained for PSNs and arterial ECs, PSNs are seen to differentiate prior to arterial ECs. 1. The recruitment and differentiation of smooth muscle cells (SMCs) to the external wall of arteries is know to be an important step in arteriogenesis. 2. In Figure 3 they show, using alpha-smooth muscle actin (alpha-SMA) as a marker for
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Unformatted text preview: SMC differentiation, that SMCs associate with developing arteries only AFTER they associate with nerves (E15.5). Note: in this series of immunostaining experiments, SMCs are labeled with red fluorescence; arterial ECs are labeled with green fluorescence (ephrinB2 and NP1). We are skipping the details of this set of experiments, because they do not provide significant or unexpected additional information; only further confirmation that it is PLAUSIBLE that PSNs direct the differention of arteries....
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This note was uploaded on 05/15/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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