Lecture30outline-1

Lecture30outline-1 - I. Review Glycolysis is the process of...

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I. Review • Glycolysis is the process of converting glucose to acetic acid derivatives • The first mechanistically interesting step proceeds the conversion of the aldopyranose glucose 6-phosphate to its open form, followed by enediol formation, protonation to form a ketone, and closure to form the ketofuranose fructose phosphate • The next interesting step proceeds through the ring opening of fructose diphosphate followed by a retro aldol reaction to form the aldotriose glyceraldehyde phosphate and the ketotriose dihydroxyacetone phosphate • Dihydroxyacetone phosphate is converted to glyceraldehyde phosphate through a Lowbry de Bruyn-Alberda van Eckenstein reaction • Glyceraldehyde 3-phosphate reacts with inorganic phosphate to form a hemiacetal-like compound that is oxidized by NAD + to form NADH and an acyl phosphate that reacts with ADP to form ATP and phosphoglyceric acid • Phosphate migration and β -hydroxy group elimination forms phosphoenol pyruvate, that releases phosphate to ADP to form ATP and pyruvic acid (via its enolate)
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Lecture30outline-1 - I. Review Glycolysis is the process of...

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