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Unformatted text preview: Conducting the Strecker synthesis with a chiral Lewis acid rather than HOAc leads to the formation of enantiomerically enriched amino nitriles that can be converted to single enantiomers of amino acids Chiral derivatives of glycine can be converted to enolates for diastereoselective addition to electrophiles to form amino acid derivatives through carboncarbon bond formation Chiral enolates can react with notrogen electrophiles like DEAD to form amino acid derivatives through carbonnitrogen bond formation Amino acids cannot be coupled efficiently in the absence of protecting groups II. More amino acid chemistry Peptide synthesis Automated synthesis Coupling large peptide fragments Problem Set 26-4, 26-5, 26-7, 26-8, 26-14, 26-16, 26-17, 26-18, 26-19, 26-20, 26-22, 26-31, 26-32, 26-38, 26-48, 26-52...
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