final - 1 BIS 101 - 003 Final March 21, 2009 READ THE...

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1 BIS 101 - 003 Final March 21, 2009 READ THE FOLLOWING INSTRUCTIONS: Write your name legibly on each page of this exam. All work must be done in ink . Show all your work. Points will be subtracted for each incorrect answer in multiple-choice questions. However, you will not receive a negative total score for such a question. This exam is worth 200 points. You have 110 min. to complete the exam. Good Luck!
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2 Name:______________________________ ID _________________________ Page: 3 ________ 4 ________ 5 ________ 6 ________ 7 ________ 8 ________ 9 ________ 10 ________ 11 ________ 12________ 13 _______ 14 ________ 15 _______ Total ________
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3 Name:_________________________ (1) Loci A and B are linked on the chromosome. The genetic distance between the loci is 10%. If the dihybrid AB / ab is testcrossed, what genotypes and in what proportions do you expect? (6 points) (2) Most of the erminette fowl (erminette is the name of the breed of chickens) are light colored with occasional black one, giving a flecked appearance. A cross of two erminettes produced a total of 48 progeny, consisting of 24 erminettes, 14 blacks and 14 pure white. (a) What genetic basis of the erminette pattern do you suggest? (4 points) (b) Test statistically your hypothesis using χ 2 test. (4 points)
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4 Name:_________________________ ( 1 ) Below is a diagram of a eukaryotic gene, its primary RNA transcript, mRNA and the polypeptide it encodes. Do the following. (14 points) (a) Label the 5' and 3' ends on all DNA and RNA strands. (b) Indicate which DNA strand is a template and which is a nontemplate. Draw in a TATA box where it should be. (c) Show where the transcript starts on the primary (nascent) transcript (shorten or elongate the line if needed). (d) Show where the mature mRNA starts and where its ends (shorten or elongate the line if needed) and draw in all modifications that distinguish it from the primary transcript. (e) In the polypeptide, indicate where it starts and where it ends relative to the landmarks on the DNA molecule (shorten or elongate the line if needed), and label the amino- and the carboxy- termini. D N A __________+1_____ATG______________________TAA___________ ___________________________________________________________ primary RNA transcript ______________________________________________________________________ mRNA ______________________________________________________________________ polypeptide ______________________________________________________________________
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5 Name:________________________ (1) Mr. and Mrs. Simpson have been trying for years to have a child but have been unable to conceive. A test revealed that Mr. Simpson has a markedly reduced sperm count. His chromosomes were studied, and testicular biopsy was done. His chromosomes proved to be normal except for chromosome pair number 12. The G banding of the chromosomes indicated that one chromosome 12 was normal but its homologue had a pericentric inversion . (a) Using an arbitrary gene sequence
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This note was uploaded on 05/17/2010 for the course BIS 101 taught by Professor Simonchan during the Winter '08 term at UC Davis.

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final - 1 BIS 101 - 003 Final March 21, 2009 READ THE...

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