bis_104_pq_28_ans_ss_i_2009 - motor protein doesnt fall off...

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BIS 104 PQ 28 ANS SS I 2009 29. It has been determined that a cargo vesicle can be moved along a microtubule (MT) toward the “plus” end at a speed of ~ 3 micrometers per second (3 um / sec). And, that each individual kinesin motor step covers ~ 8 nanometers (nm). a. How many steps can a kinesin molecule make in one minute? 22,500 steps per minute or 375 steps per second b. A neuron has to transport acetylcholine packaged in a vesicle from near the nucleus, down the axon, to the tip for release at a synapse. The length of the axon is 600 um. Assuming the kinesin
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Unformatted text preview: motor protein doesnt fall off the MT, how many minutes will it take to deliver the cargo vesicle? 3.3 minutes c. What three cellular parameters might influence the rate of cargo transport? Availability of ATP; Frictional resistance of the environment (viscosity of cytoplasm and bulk of the cargo) d. After kinesin motor proteins and dyneins transport their cargos to one end of a microtubule, how do you suppose these proteins get back to their origin? They may be carried back by other motor proteins that follow the opposite polarity of the MT....
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This note was uploaded on 05/17/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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