BICD 110-lec7

BICD 110-lec7 - BICD 110 Ch7 Endoplasmic reticulum protein...

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BICD 110: Ch7: Endoplasmic reticulum: protein and lipid synthesis and modification I. outer membrane of nucleus is continuous with the ER II. Protein synthesis: a. Transmembrane and water soluble proteins and synthesized in the ER and translocated across ER membrane from cytosol into lumen III. The rough ER a. Studded with ribosome’s b. When proteins are translated, the proteins are already being translocated into membrane. Cotranslational process so we do not need chaperones.
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IV. a. the mrna that econdes transmembrane or soluble proteins have singal sequences that will be recognized by the SRP cycle, which will bring partially synthesize protein to ER membrane b. those that do not have signal recognition particle will stay in the cytosol. V. Smooth ER a. Does not have ribosome’s b. Not abundant
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i. Hepatocytes (liver cell) ii. A sreriod secreting cell. c. More tubular. d. Involved in lipid synthesis e. Liver: i. Detoxification in liver. f.
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BICD 110-lec7 - BICD 110 Ch7 Endoplasmic reticulum protein...

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