Lecture8 - Summary 1. 2. 3. 4. 5. 6. Rough ER and smooth...

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Summary 1. Rough ER and smooth ER; 2. Signal hypothesis, translocation into ER; 3. Single-span and multi-span membrane proteins; 4. Glycosylation; 5. Protein folding; 6. Lipid synthesis
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Lecture 8 Vesicular trafficking from ER to Golgi
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Endocytic and biosynthetic-secretory pathways Transport vesicles (Ten or more chemically distinct, membrane-enclosed compartments)
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The biosynthetic-secretory and endocytic pathways
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Various types of coated vesicles Golgi apparatus Plasma ER and Golgi Cisternae
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Assembly of a clathrin coat triskelion Coated pits and vesicles on the cytosolic surface of membranes 36 triskelions 12 pentagons 6 hexagons Inner layer binds adaptins “cage”
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Adaptin binds to cargo receptor and clathrin triskelion Dynamin pinches off the bud Four types of adaptins Auxillin-activated ATPase is required To remove the clathrin coat Vesicles can have different shapes
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Dynamin pinches of the vesicles GTPase Shibire mutant has coated pits but no budding off of synaptic vesicles
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This note was uploaded on 05/18/2010 for the course BICD BICD 110 taught by Professor Zao during the Spring '09 term at UCSD.

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Lecture8 - Summary 1. 2. 3. 4. 5. 6. Rough ER and smooth...

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