Lecture9 - Summary 1 Vesicular transport...

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Summary 1. Vesicular transport, biosynthetic-secretory and endocytic pathways; 2. Coated vesicles; 1. Coat assembly and disassembly, budding, dynamin, coat-recruitment GTPases; 1. Targeting and fusion by Rab GTPases, SNAREs; 2. ER to Golgi: COPII, folding, fusion (cluster), retrograde; 3. Golgi apparatus structure and polarity; 4. Continuation of glycosylation; 5. Compartmentalization of Golgi cisternae; 6. By now we have introduced gated transport, transmembrane transport and vesicular transport.
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Lecture 9 Vesicular Transport: From the trans Golgi to lysosomes; endocytosis and exocytosis
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pH is one of the mechanisms for protecting contents in the cytosol Vacuolar H + ATPase: Lysosomes Endosomes Selected compartments of Golgi Apparatus Transport vesicles Secretory vesicles All major classes of macromolecules are degraded in lysosomes Lysosomal glycoproteins are unusually highly glycosylated 40 hydrolytic enzymes
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Lysosomes are highly heterogeneous Shape and size But all have acid hydrolases The “stomach” of a cell Stained for acid phosphatase: Phosphatase substrate
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Huge vacuoles of plant cells Related to lysosomes Storage organelle Degradative compartments Turgor pressure Homeostatic device (pH, osmotic pressure) Rubber Opium Garlic Proteins Pigments Noxious molecules
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This note was uploaded on 05/18/2010 for the course BICD BICD 110 taught by Professor Zao during the Spring '09 term at UCSD.

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Lecture9 - Summary 1 Vesicular transport...

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