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Lecture60 - Summary 1 Ions and larger polar molecules...

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Summary 1. Ions and larger polar molecules cannot cross the lipid bilayer; 2. Two types of transport proteins: carriers (transporters) and channels; 3. Passive and active transport; 4. Three types of active transport; 5. Mechanisms of cotransport; 6. Na + -K + pump and ABC transporters; 7. Channels: voltage-gated and ligand-gated; 8. Selectivity of K + channels; 9. Action potential, voltage-gated Na + channel, voltage- gated K + channel, myelination; 10. Neuromuscular junction as an example of synapse, functions of ion channels.
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Lecture 6 Intracellular Compartments and Protein Sorting This week’s office hour is moved to 2-3 pm Friday
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Membrane-enclosed compartments Proteins in organelles: enzymes, transporter and surface markers 10,000-20,000 proteins synthesized in cytosol and delivered to different compartments
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Major intracellular compartments Vital chemical reactions take place in or on membrane surface Compartments increase surface and isolate reactions
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Microtubules help the localization of the ER and the Golgi apparatus Bacteria have no Internal membranes Eukaryotic cells are 1000-10,000 times greater in volume-- need internal membranes A liver cell
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Topologically equivalent spaces are shown in red
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Gated transport Transmembrane transport Vesicular transport Transport is highly regulated Three types of transport
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Vesicle budding and fusion during vesicular transport Both membrane proteins and soluble proteins are transported
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Signal sequence
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