BICD 140 � Ch2 notes

BICD 140 � Ch2 notes - BICD 140 Ch2 notes Innate...

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BICD 140 – Ch2 notes Innate Immunity I. A variety of defense mechanisms have evolved to eliminate the different types of pathogens a. A distinction: pathogens that replicate and live in the extracellular space produce extracellular infections while those that lived inside the cell produce intracellular infections i. Extracellular forms are accessible to soluble molecules of immune system, while intracellular forms are not. ii. Intracellular pathogens that lice in the nucleus or cytosol can be attacked by killing the cell b. Most pathogens affect few related host species, so it is diffcult to transmit between species. Human infections normally result person to person while some need an intermediate passage through a distantly related organism, such as insects. c. Ability of pathogens to live outside the body varies: i. Anthrax: spread by spores, temp resistant and can be passed over long distances ii. HIV is sensitive to changes in environment which is why it can be passed by intimate contact and exchange of infected body fluids II. Complement is a system of plasma proteins that marks pathogens for destruction a. First weapon to fire is the complement system i. Most important is C@ where C3b binds to pathogen and tags it for
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This note was uploaded on 05/18/2010 for the course BICD bicd 100 taught by Professor Soowal during the Spring '08 term at UCSD.

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BICD 140 � Ch2 notes - BICD 140 Ch2 notes Innate...

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