NM%20-%20Handout%204

NM%20-%20Handout%204 - BIPN 102 Spring 2010 Ni Mo Week 5...

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BIPN 102 – Spring 2010 Ni Mo Week 5: Handout #4 [email protected] Material Covered: Lecture 8 OH: Friday 10-11am PC East Henderson-Hasselbalch Equation pH = pKa + log ([A - ]/[HA]) 7.4 = 6.1 + log([HCO3-]/[H2CO3]) 7.4 = 6.1 + log[24/1.2] (see below) Normal physiological values: pKa of H2CO3 = 6.1 [HCO3-] = 24mmol [H2CO3] = PCO2 x solubility = (40mmHg)(0.03 mmol/mmHg) = 1.2mmol From these values, the normal [HCO3-]/[H2CO3] ratio = 24/1.2 = 20 Therefore, if the ratio <20, the pH < 7.4, and you have acidosis. If ratio > 20, pH > 7.4, then you have alkalosis. Dr. House receives the following lab results for arterial blood of a patient: PACO2 = 50mmHg, HCO3- = 15mM, pH = 7.53 Write the Henderson-Hasselbalch equation with the lab data above: What is Dr. House’s diagnosis? (Normal, or list the type of acid/base imbalance, or laboratory error?) Cells (yes, you  do  need to memorize these cells for the upcoming exams!) Proximal Tubule Cell: Channels/enzymes present (remember them!): 1. 2. 3. 4. Type A/B Intercalated Cells: Type A Responds to A cidosis. Type B Responds to B ase (alkalosis) Channels/enzymes present (Type A): 1. 2.
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