NM%20-%20Handout%204

# NM%20-%20Handout%204 - BIPN 102 Spring 2010 Ni Mo Week 5...

This preview shows pages 1–2. Sign up to view the full content.

BIPN 102 – Spring 2010 Ni Mo Week 5: Handout #4 [email protected] Material Covered: Lecture 8 OH: Friday 10-11am PC East Henderson-Hasselbalch Equation pH = pKa + log ([A - ]/[HA]) 7.4 = 6.1 + log([HCO3-]/[H2CO3]) 7.4 = 6.1 + log[24/1.2] (see below) Normal physiological values: pKa of H2CO3 = 6.1 [HCO3-] = 24mmol [H2CO3] = PCO2 x solubility = (40mmHg)(0.03 mmol/mmHg) = 1.2mmol From these values, the normal [HCO3-]/[H2CO3] ratio = 24/1.2 = 20 Therefore, if the ratio <20, the pH < 7.4, and you have acidosis. If ratio > 20, pH > 7.4, then you have alkalosis. Dr. House receives the following lab results for arterial blood of a patient: PACO2 = 50mmHg, HCO3- = 15mM, pH = 7.53 Write the Henderson-Hasselbalch equation with the lab data above: What is Dr. House’s diagnosis? (Normal, or list the type of acid/base imbalance, or laboratory error?) Cells (yes, you  do  need to memorize these cells for the upcoming exams!) Proximal Tubule Cell: Channels/enzymes present (remember them!): 1. 2. 3. 4. Type A/B Intercalated Cells: Type A Responds to A cidosis. Type B Responds to B ase (alkalosis) Channels/enzymes present (Type A): 1. 2.

This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

### What students are saying

• As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

Kiran Temple University Fox School of Business ‘17, Course Hero Intern

• I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

Dana University of Pennsylvania ‘17, Course Hero Intern

• The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

Jill Tulane University ‘16, Course Hero Intern