BIPN 102-lec1notes

BIPN 102-lec1notes - BIPN 102 Lecture 1 Respiration...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
BIPN 102- Lecture 1 Respiration: Cellular: in mitochondria electron transport, oxidative respiration We are interested in external respiration Respiratory system carries out series of functions that has verity of challenges due to the physics of the process Must exchange gases with outside to inside of lungs—this is called ventilation. There is a dead space where are in and air out come in and out of the same pathway Challenges: Physical property, dead space, air that occupies the air ways which was the air that comes out of lungs goes back in, and dilutes the fresh air that is just coming in. when we expire, the fresh air is the first to come out. One of the challenges is how do we get air in an out, this rqs muscle contraction, and the fact that the lungs need to be expanded, and the challenge is how to expand them with using minimal energy since we are always breathing Next challenge, air must dissolve into blood, solubility of gases is very low. As we increase temperature, the solubility goes even lower. The solubility of oxygen in 20x lower than that of co2. Co2 reacts with water to form carbonic acid and bicarbonate which Is water solubility and o2 reacts with hemoglobin Functions: Exchange of gases, o2 and co2 between blood and gas phase, this is called diffusion. know ficks law. Transport of gases in blood. At level of capillaries we have the equilvalent change between capillaries and cells. Co2 and o2 difffuse down concentration gradient to and from mitochondira Heart, pulmonary and systemic circulation. Remember, pulmonary circulation has all of the cardiac output going to lungs whereas systemic circulation has all ouput going to the rest of the body. Pulmonary is faster than systemic circulation. Challenge matching blood flow with diffusion of gases. Pulmonary circulation at rest, RBC spends 3/4s in the capillary, Only place where gas exchange to occur. Time for as exchange= 34s. diffusion
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
must be fast enough so in the ¾ s, co2 has equilibrated in the blood and alveolar air, and o2 has equilibrate between alveolar air and blood. When we exercise, output can increase 30l/min, blood flow increases rapidly, then there is only about 1/4s for equilibration to occur. We must match perfusion and diffusion Pulmonary is a low pressure low resistance system. All it needs is to pump to the top of the lungs (about a foot) mean arterial pressure in pulmonary system is 15mmHg, and the resistance to blood flow in pulmonary is 1/6 of that in systemic circulation. As an example, if you were to use a straw, you would need to apply pressure to suck fluid, it is 6x more in pulmonary circulation, for the same flow. So you would need 1/6 less suction for the same flow. Anatomy: We can distinguish upper respiratory tract: nasal cavity, oral cavity, pharynx, Enter: airways: larynx (uppermmost) contains: glottis (vocal chords). There is a cover to the glottis, called the epiglottis, and when we swallow, you will notice that larynx goes up and the opening is covered. The glottis also vibrate to make sound. We make diff ppitches by tensing or relaxing and changing the opening. Low sounds open glottis, high
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern