BIPN 102-lec1notes

BIPN 102-lec1notes - BIPN 102- Lecture 1 Respiration:...

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BIPN 102- Lecture 1 Respiration: Cellular: in mitochondria electron transport, oxidative respiration We are interested in external respiration Respiratory system carries out series of functions that has verity of challenges due to the physics of the process Must exchange gases with outside to inside of lungs—this is called ventilation. There is a dead space where are in and air out come in and out of the same pathway Challenges: Physical property, dead space, air that occupies the air ways which was the air that comes out of lungs goes back in, and dilutes the fresh air that is just coming in. when we expire, the fresh air is the first to come out. One of the challenges is how do we get air in an out, this rqs muscle contraction, and the fact that the lungs need to be expanded, and the challenge is how to expand them with using minimal energy since we are always breathing Next challenge, air must dissolve into blood, solubility of gases is very low. As we increase temperature, the solubility goes even lower. The solubility of oxygen in 20x lower than that of co2. Co2 reacts with water to form carbonic acid and bicarbonate which Is water solubility and o2 reacts with hemoglobin Functions: Exchange of gases, o2 and co2 between blood and gas phase, this is called diffusion. know ficks law. Transport of gases in blood. At level of capillaries we have the equilvalent change between capillaries and cells. Co2 and o2 difffuse down concentration gradient to and from mitochondira Heart, pulmonary and systemic circulation. Remember, pulmonary circulation has all of the cardiac output going to lungs whereas systemic circulation has all ouput going to the rest of the body. Pulmonary is faster than systemic circulation. Challenge matching blood flow with diffusion of gases. Pulmonary circulation at rest, RBC spends 3/4s in the capillary, Only place where gas exchange to occur. Time for as exchange= 34s. diffusion
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must be fast enough so in the ¾ s, co2 has equilibrated in the blood and alveolar air, and o2 has equilibrate between alveolar air and blood. When we exercise, output can increase 30l/min, blood flow increases rapidly, then there is only about 1/4s for equilibration to occur. We must match perfusion and diffusion Pulmonary is a low pressure low resistance system. All it needs is to pump to the top of the lungs (about a foot) mean arterial pressure in pulmonary system is 15mmHg, and the resistance to blood flow in pulmonary is 1/6 of that in systemic circulation. As an example, if you were to use a straw, you would need to apply pressure to suck fluid, it is 6x more in pulmonary circulation, for the same flow. So you would need 1/6 less suction for the same flow. Anatomy:
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This note was uploaded on 05/18/2010 for the course BICD bicd 100 taught by Professor Soowal during the Spring '08 term at UCSD.

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BIPN 102-lec1notes - BIPN 102- Lecture 1 Respiration:...

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