040610 lec3

040610 lec3 - BIPN144 FIG 1-7: The regulatory region of a...

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BIPN144 FIG 1-7: The regulatory region of a gene dpp is a signal and elicits a response in other cells. I. Two basic types of patterning molecules
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a. Transcription factors. i. Proteins that bind DNA in regulatory regions and turn on (Activators) or off (repressors) transcription b. Secreting signal factors (growth factors) i. Proteins secreted from cells and diffuse to neighboring cells ii. Growth factor binds to receptors on neighboring cell surfaces iii. Growth factor Receptors send signal inside cell to nucleus iv. Transcription factor activates change v. Target genes get turned on or off. II. Morphogens a. Factors present in graded concentration i. Produced in one group of cells and diffuses into cells that do not make it. ii. Transcription factors can also be morphogens b. Factors elicits different responses at diff concentrations
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c. i. in order to get a graded distribution, you need an adjacent source and sink. III. Early D-V Axis Establishment in flies.
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This note was uploaded on 05/18/2010 for the course BIPN BIPN 102 taught by Professor Fortes during the Spring '09 term at UCSD.

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040610 lec3 - BIPN144 FIG 1-7: The regulatory region of a...

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