BIPN 144-LEC9

BIPN 144-LEC9 - will become GMC 1. So bazooka signals the...

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gBIPN 144-Lecture 9 - 4/22/10 I. Localized Determinants and neuronal fate specification a. i. localized determinants: molecule that is asymmetrically distributed during a cell division that influences the fate of the cell that inherits. 1. Central NS:
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a. Neuroblast delaminates and becomes stem cell which divides and is renewed. 2. Peripheral NS: a. SOP delaminates (sensory organ precursor) b. IIa1 IIb 3. Lateral inhibition – determines spacing of neuroblasts and SOPs a. The neuroblasts divides along the line, neuro is the top, the ganglion mother cell is the bottom (GMC) i. GMC divides to become 2 neurons. 1. The neurons send out axon to create NS ii. Bazooka signals from skin to neuro, and sends out Inscrutable/pins inhibit the accumulation of numb, propero, Miranda (localized determinates), the side that
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Unformatted text preview: will become GMC 1. So bazooka signals the upper cell to at least stay neuroblasts and the bottom becomes GMC and then eventually neurons. iii. After GMC forms, in the neuroblasts, the molecules are produced evenly. (inscrutable and pins), until inscrutable and pins start to accumulate at the top again. II. Cell Fate specification in PNS lineages a. i. md- multiple dendrite – touch receptor. ii. ES- external sensory organ 1. If hair is tweaked, it rocks back and forth in it socket. The dentrite is mechanically signaled and there us an AP down to the neuron to axon. The glial cell wraps around dendrite to help AP travel down dendrite. iii. SHO- stretch receptor. 1. the receptor gets stretched, cap cell pills on neuron and AP is made....
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This note was uploaded on 05/18/2010 for the course BIPN BIPN 102 taught by Professor Fortes during the Spring '09 term at UCSD.

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BIPN 144-LEC9 - will become GMC 1. So bazooka signals the...

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