Topic 4 - Membrane Structure and Function S10 1pp

Topic 4 - Membrane Structure and Function S10 1pp - Topic 4...

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1 Membrane Structure and Function Topic 4 Chapter 7
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2 Outline Phospholipid Bilayer Fluid Mosaic Model Membrane Proteins Diffusion Facilitated Diffusion Osmosis Osmotic Balance Active Transport Bulk Transport
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3 Objectives I To understand or know: The chemical nature of the components of a membrane The fluid mosaic model of membrane structure and function The concept of a selectively permeable barrier The organization of the plasma membrane (PM) The 6 functions of PM proteins Membrane protein structure How diffusion occurs
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4 Objectives II What osmosis is and how it works The difference between a hypertonic, a hypotonic and an isotonic solution How cells of different organisms maintain osmotic balance and active transport How active transport is related to coupled transport What endocytosis and exocytosis are and how they work The three types of endocytosis
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5 Key Words and Key Phrases Phopholipid bilayer; fluid mosaic model; selectively permeable barrier; concentration gradient Transporter; receptor; identity marker; adhesion protein Transmembrane protein; anchor; channel; carrier; pore Diffusion; Fick’s law; facilitated diffusion; osmosis; aquaporin Osmotic concentration; hypotonic; hypertonic; isotonic; hydrostatic pressure; osmotic pressure; turgor Endocytosis; phagocytosis; pinocytosis; receptor-mediated enocytosis; exocytosis Active transport; sodium-potassium pump; proton pump; coupled transport
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6 OVERVIEW The plasma membrane is the boundary that separates the living cell from its surroundings The plasma membrane exhibits selective permeability , allowing some substances to cross it more easily than others
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7 Phospholipid Bilayer (Review) Phospholipid has two fatty-acid chains attached to its backbone. One end is strongly nonpolar while the other end is strongly polar = amphipathic polar head oriented toward water and nonpolar tails oriented away from water bilayer is stable because water’s affinity for hydrogen bonding never stops so maintains phospholipid orientation
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8 Phospholipid Structure (Review)
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9 Fluid Mosaic Model Plasma membrane is composed of both lipids and globular proteins In 1972, J. Singer and G. Nicolson proposed that the membrane is a mosaic of proteins dispersed within the bilayer, with only the hydrophilic regions exposed to water Membrane proteins are not very soluble in water Inserted into the lipid bilayer A mosaic of proteins float in the fluid, lipid bilayer Selectively permeable barrier
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10 Hydrophilic head WATER Hydrophobic tail WATER
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11 Phospholipid bilayer Hydrophobic regions of protein Hydrophilic regions of protein
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12 Freeze-fracture studies of plasma membrane supported the fluid mosaic model Freeze-fracture = specialized preparation technique
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This note was uploaded on 05/18/2010 for the course BIO 188 taught by Professor Capco during the Spring '08 term at ASU.

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Topic 4 - Membrane Structure and Function S10 1pp - Topic 4...

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