Topic 8 Part A Cell communication BIO188 S10 1pp

Topic 8 Part A Cell communication BIO188 S10 1pp - Cell...

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1 Cell Communication Topic 8 Chapter 11
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2 OBJECTIVES To know or understand: The general concept of a signal transduction pathway The 3 levels and 4 types of intercellular signaling What phosphorylation and dephosphorylation are and which enzymes mediate each process What the 2 types of receptors are and the general mechanism of their function How intracellular receptors function How steroid hormone receptors function How intracellular receptor enzymes function The three different types of cell surface receptors The mechanisms by which a signal is transduced What a second messenger is and their types How a signal is amplified
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3 OBJECTIVES II To know or understand: What a receptor tyrosine kinase is How the insulin receptor works to regulate blood glucose levels How protein kinase cascades amplify a signal How receptors are inactivated G protein is
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4 OBJECTIVES III To know or understand: Where Ca 2+ 2+ /calmodulin complex is functions 1 example of function for each type The 3 types of cell junctions & their functions
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5 KEY WORDS and PHRASES Signal; signal transduction pathway; lignad; receptor; transduction; effect Direct contact ; paracrine signaling; endocrine signaling; synaptic signaling; autocrine signaling Phosphorylation; dephosphorylation; kinase; phosphatase; autophosphorylation Intercellular receptor; nuclear receptor; cell surface receptor; chemically-gated ion channel; enzyme receptor; steroid hormone receptor; Receptor tyrosine kinase (RTK); G protein-coupled receptors (GPCRs); Ras; mitogen-activated protein (MAP) kinase; cGMP Second messenger; cAMP; calcium; IP 3 ; CaM; signal cascade; protein kinase cascade Glycolpids; major histocompatibility complex (MHC) Tight junctions; anchoring junctions; communicating junctions; gap junctions; plasmodesmata
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6 Overview cell-to-cell communication absolutely essential for multicellular organisms cells must communicate to coordinate activities e.g. nervous signals; hormones communication between cells also important for many unicellular organisms e.g. getting together for sex signaling nutrient availability in soil bacteria Biologists have discovered some universal mechanisms of cellular regulation The combined effects of multiple signals determine cell response
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This note was uploaded on 05/18/2010 for the course BIO 188 taught by Professor Capco during the Spring '08 term at ASU.

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Topic 8 Part A Cell communication BIO188 S10 1pp - Cell...

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