Topic 8 Part B Cell-cell communication BIO188 F09 1pp-1-1

Topic 8 Part B Cell-cell communication BIO188 F09 1pp-1-1 -...

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Unformatted text preview: 1 Cell-Cell Interactions Topic 8 Part B Chapter 11 2 OBJECTIVES To know or understand: The general concept of a signal transduction pathway The 3 levels and 4 types of intercellular signaling What phosphorylation and dephosphorylation are and which enzymes mediate each process What the 2 types of receptors are and the general mechanism of their function How intracellular receptors function How steroid hormone receptors function How intracellular receptor enzymes function The three different types of cell surface receptors The mechanisms by which a signal is transduced What a second messenger is and their types How a signal is amplified 3 OBJECTIVES II To know or understand: What a receptor tyrosine kinase is How the insulin receptor works to regulate blood glucose levels How protein kinase cascades amplify a signal What a scaffold protein is & its function How G protein coupled receptors function & what a G protein is 4 OBJECTIVES III To know or understand: How signal pathways are inactivated What a second messenger is Where Ca 2+ comes from & what the Ca 2+ /calmodulin complex is The 2 major types of cell surface molecules & their functions 1 example of function for each type The 3 types of cell junctions & their functions 5 KEY WORDS and PHRASES Signal; signal transduction pathway; lignad; receptor; transduction; effect Direct contact ; paracrine signaling; endocrine signaling; synaptic signaling; autocrine signaling Phosphorylation; dephosphorylation; kinase; phosphatase; autophosphorylation Intercellular receptor; nuclear receptor; cell surface receptor; chemically-gated ion channel; enzyme receptor; steroid hormone receptor; Receptor tyrosine kinase (RTK); G protein-coupled receptors (GPCRs); cGMP Second messenger; cAMP; calcium; IP 3 ; CaM; signal cascade; protein kinase cascade Glycolpids; major histocompatibility complex (MHC) Tight junctions; anchoring junctions; communicating junctions; gap junctions; plasmodesmata 6 TRANSDUCTION Signal transduction usually involves multiple steps Multistep pathways can amplify a signal A few molecules can produce a large cellular response Multistep pathways provide more opportunities for coordination and regulation of the cellular response The molecules that relay a signal from receptor to response are mostly proteins Like falling dominoes, the receptor activates another protein, which activates another, and so on, until the protein producing the response is activated At each step, the signal is transduced into a different form, usually a shape change in a protein 7 In many pathways, the signal is transmitted by a cascade of protein phosphorylations Signaling molecule Receptor Activated relay molecule Inactive protein kinase 1 Active protein kinase 1 Inactive protein kinase 2 AT P AD P Active protein kinase...
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This note was uploaded on 05/18/2010 for the course BIO 188 taught by Professor Capco during the Spring '08 term at ASU.

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Topic 8 Part B Cell-cell communication BIO188 F09 1pp-1-1 -...

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