Topic 13-Control of Gene Express S10 1pp

Topic 13-Control of Gene Express S10 1pp - Control of Gene...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Control of Gene Expression Topic 13 Chapter 18
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Objectives I Why is regulation of gene expression important? eukaryotes? Know what binding proteins do. Know the 4 different types of DNA binding motifs. How does the lac operon work? How does the trp operon work What are the fundamental differences in transcriptional regulation in eukaryotes vs. prokaryotes? the difference between them?
Background image of page 2
3 OBJECTIVES II What is an activator? What are promoters and enhancers? How do they work? What are coactivators and mediators? How do they work? How does chromatin structure impact eukaryotic gene expression? How is chromatin structure modified? Define posttranscriptional control of gene expression? What are the major mechanisms of posttranscriptional control? come from? What is alternative splicing Why are proteins degraded and how are they marked for degradation? What is the ubiquitin-proteosome pathway?
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Key Words and Phrases Regulatory proteins; homeostasis; binding proteins; RNA polymerase; promoter; transcriptional control; major groove; DNA-binding motifs; helix-turn-helix motif; homeodomain motif; zinc-finger motif; leucine zipper motif Negative control; positive control; Repressor; operator; effector molecules; operon; activator; lac operon; lactose; alolactose; trp operon; tryptophan; induction; repression; glucose repression; catabolite activator protein (CAP); inducer exclusion; repressed; derepressed
Background image of page 4
5 general transcription factors; specific transcription factors / activators; enhancer; promoter; coactivator; mediator Transcription complex; initiation complex; Chromatin; nucleosome; methylation; acetylation; histone code; chromatin remodeling complex; posttranscriptional regulation; small RNA; small interfering RNA (siRNA); micro RNA (miRNA); RNA interference; alternative splicing Proteases; ubiquitin; ubiquitination; proteosome; ubiquitin-proteosome pathway
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 Introduction All genes are not expressed at all times in an organism Different genes are expressed at different times and under different physiological conditions In prokaryotes allows cell to take advantage of changing environmental conditions In multi-cellular organisms different genes are expressed in different cell types ! homeostasis ! = greater complexity Regulatory regions of DNA sequence determine which genes are expressed where and when RNA molecules play many roles in regulating eukaryotic gene expression
Background image of page 6
7
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/18/2010 for the course BIO 188 taught by Professor Capco during the Spring '08 term at ASU.

Page1 / 63

Topic 13-Control of Gene Express S10 1pp - Control of Gene...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online