biochem exam 3

biochem exam 3 - Biochem 581 take home exam Chapter 13-16...

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Biochem 581 take home exam Chapter 13-16 Please answer each question (10 points each) with complete sentences. Email (dbhansen@rutgers.edu) your answers to me by May 12 6pm. 1. In the adenylate cyclase signaling pathway would a GTP S analogue of GTP which γ binds similarly to GTP but cannot be hydrolyzed affect cAMP levels if bound to a stimulatory G α subunit and why? 2. A growth factor that acts through a receptor tyrosine kinase stimulates cell division, predict the effect of viral protein that inhibits the pathway’s corresponding phosphatase. 3. Gleevec was a major breakthrough in the treatment of chronic mylogeneous leukemia caused by Bcr-Abl a mutant kinase, explain why gleevec was a successful drug in comparison to other known inhibitors of Bcr-Abl that work through competitive inhibition of ATP binding? 4. While inorganic pyrophosphatase is not in directly involved in the synthesis of glycogen it is key enzyme. Explain the effects on glycogen biosynthesis if inorganic pyrophosphatase was absent? 5.
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biochem exam 3 - Biochem 581 take home exam Chapter 13-16...

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