Notes 10-8-08

Notes 10-8-08 - Translation follows transcription Promoter...

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Translation follows transcription Promoter is the binding site of the sigma subunit of the RNA polymerase, 3’ to 5’ strand is the template; always called primary mRNA for both prok. And eukar But prokaryote mRNA does not undergo any modifications, as it does in eukaryotes First step of translation is initiation; ribosome binding site on the mRNA (series of nucleotides) is recognized by the 16s rRNA of the small subunit of ribosomes -next the star codon (AUG=UAC anticodon on tRNA carrying methaionine); large subunit attached to small sunbunit in such a way that EPA sites are formed, with the intiator methaionine occupying the psite -aminoacyl tRNA comes to the A site peptitidyl transferase reaction catalyzed by rRNA translocation of peptide from A site to P site is the most energy costly stage of the cycle, requires 2 GTP -once the stop codon reaches, there is no corresponding tRNA; release factor protein arrives at the A site (shaped similar to tRNA); cleaves the peptide by hydrolysis; causes the separation of the risbomal subunits (requires energy) free to restart the cyle for each tRNA charged by an amino acid, use the tRNA synthetase reaction (amino acid,
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This note was uploaded on 05/20/2010 for the course BIOL 101 taught by Professor Fevzidaldal during the Fall '08 term at UPenn.

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Notes 10-8-08 - Translation follows transcription Promoter...

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