Unformatted text preview: scanning confocal fluorescence microscopy. (10) Describe the RESULTS that were obtained. Normal: Staining of sensory nerves (2H3) and arterial (CX40) staining patterns were co-incident with each other. PECAM-1 staining showed normal background network of relatively undifferentiated endothelial cells. Ngn-1/2 mutant : Lacked significant nerve (2H3) staining and CX40 staining was absent or greatly reduced. PECAM-1 staining was normal as in wild type mice. What may be CONCLUDED from these results? (be sure to use precise Rules of Evidence terminology). Peripheral sensory nerves are required (necessary) for arterial endothelial cell differentiation (branching and CX40 expression) . Demo...
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- Spring '08
- Biology, Atherosclerosis, Blood vessel