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Unformatted text preview: dimerization of receptors; auto-phosphorylation phosphorylation of insulin receptor substrates (IRSs) increase GLUT-4 receptor on PM glucose uptake; polymerization (glycogen synthesis) lipid and protein synthesis cell proliferation d. Phosphorylatcd IRSs provide docking and activation stations for proteins with SH2 (src homology- 2) domains (high affinity for phospho-tyrosines) Example: P13K binds to IRS P13K phosphorylatcs PIP to make PIP2 and PIP3 PIP2 localizes at PM inner leaflet Bound PIP2 recruits protein kinase B (PKB) to membrane PDK1 phosphorylatcs PKB PKB stimulates protein synthesis; glucose uptake, glycogen synthesis A divergent signaling pathway. A single ligand (insulin) stimulates multiple cascade pathways. Demo...
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This note was uploaded on 05/24/2010 for the course BIS 104 taught by Professor Scholey during the Spring '08 term at UC Davis.
- Spring '08