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lecture_5.page3 - Sickle cell anemia glu —> val at...

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Unformatted text preview: Sickle cell anemia glu —> val at position 6 in the B chain of hemoglobin Abnormal hemoglobin Sickling of red blood cells Destruction of cells Clumping of cells Collection in spleen Spleen hypertrophy Anemia Local failure of blood supply to: Heart Lungs Kidney Brain G—I Muscles and joints Failure Pneumonia Failure Rheumatism "Tower skull" Impaired mental function Weakness, poor physical development Pleiotropy ...
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