Unformatted text preview: Sickle cell anemia glu —> val at position 6 in the B chain of hemoglobin
Abnormal hemoglobin Sickling of red blood cells Destruction of cells Clumping of cells Collection in spleen
Anemia Local failure of blood supply to:
Heart Lungs Kidney Brain G—I Muscles and joints
Failure Pneumonia Failure Rheumatism "Tower skull"
Impaired mental function
Weakness, poor physical development Pleiotropy ...
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- Winter '08