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Unformatted text preview: potentials is mostly removed from the cytoplasm, but a small amount remains. Because the probability of neurotransmitter release is proportional to [Ca++] 4 , this effect is very non-linear, so a small amount of residual calcium can have a big effect on the amount of transmitter released (by greatly increasing the number of vesicles binding), and therefore on the increased size of the EPSP. 3a. How would you calculate the membrane potential of a cell? Use the GHK Equation RT/F(p K +[ K + ] o + p Na + [Na+] o + p Cl-[Cl-] i ) /( p K +[ K + ] i + p Na + [Na+] i + p Cl-[Cl-] o) 3b. A cells membrane potential is 70 mV, and the concentration of chloride is equal inside and outside of the cell. If you apply neurotransmitter which opens a ligand-gated chloride channel, will the post-synaptic potential be hyperpolarizing or depolarizing? Depolarizing. 3c. Explain your answer to 3b. Demo...
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This note was uploaded on 05/24/2010 for the course BIS BIS102 taught by Professor Hilt during the Winter '08 term at UC Davis.
- Winter '08