11 - 2289 Radiotherapy Following Extrapleural Pneumonectomy(EPP for Mesothelioma The Brigham and Women’s Hospital Experience R Den 1 E.H Baldini

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Unformatted text preview: 2289 Radiotherapy Following Extrapleural Pneumonectomy(EPP) for Mesothelioma: The Brigham and Women’s Hospital Experience R. Den, 1 E.H. Baldini, 1 D.J. Sugarbaker, 2 J. Wong, 1 B.E. Johnson, 3 P.A. Janne, 3 R. Bueno, 2 A.M. Allen 1 1 Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women’s Hospital, Boston, MA, 2 Thoracic Surgery, Brigham and Women’s Hospital, Boston, MA, 3 Medical Oncology, Dana-Farber Cancer Institute, Boston, MA Purpose/Objective: We have previously published the world’s largest series of patients undergoing EPP for malignant pleural mesothelioma (MPM). (Sugarbaker et al. JCTS 99’) Building on those results we have published the patterns of failure of patients treated with low dose hemithoracic radiation of 30-40Gy (Baldini et al. Ann Thor Surg 97’) demonstrating a benefit to post-operative RT but with a high local failure rate of 65%. Following that publication, two attempts at the BWH/DFCI have been made to improve local control. The first was moderate dose RT 40Gy with concurrent platinum based chemotherapy andbeen made to improve local control....
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This note was uploaded on 05/24/2010 for the course MD 23 taught by Professor Tarc during the Spring '10 term at Anadolu University.

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