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Unformatted text preview: in the CD arm ( p = 0.015, Fisher’s exact test). The OO and CD groups were well-matched for MLD and V20. Median MLD, V5, V10, V15, V20, V25, and V30 for evaluable pts were 18 Gy, 52%, 44%, 39%, 35%, 32%, and 29%. Avg MLD was 1748 cGy in G0-1 and 2013 cGy in G2-5 groups ( p = 0.12). G2-5 toxicity developed in 2.2% of pts with MLD \ 18 Gy and in 19% of pts with MLD . 18 Gy ( p = 0.015, Fisher’s exact test). Mean V20 was 33.7% in G0-1 and 37.7% in G2-5 groups ( p = 0.29). 80% of pneumonitis cases oc- curred with V20 . 35%. Rate of G2-5 was 4.8% in pts with V20 \ 35% and 17% for V20 . 35%. Mean FEV1/V20 was 0.079 and 0.061 for the G0-1 and G2-5 groups ( p = 0.38). There was no difference in mean FEV1/V20 between OO and CD groups. Mean V5, V10, V15, V20, V25, V30, age, smoking history, and tumor characteristics did not differ between G0-1 and G2-5 groups. Conclusions: Overall rates of G2-5 pneumonitis were 7% in pts treated with concurrent P/E and XRT. In this analysis, predictive factors for pneumonitis were MLD . 18 Gy and receiving CD following concurrent chemoradiotherapy. There was a trend for de- veloping pneumonitis with V20 . 35%. FEV1 and FEV1/V20 were not predictive of toxicity in this study. Author Disclosure: R.B. Barriger, None; J.C. Aseneau, None; M. Yu, None; C. Reynolds, Sanofi-Aventis, E. Ownership Interest; P. Mantravadi, None; M. Neubauer, None; A.J. Fakiris, None; A. White, None; N. Hanna, None; R.C. McGarry, None. 1012 Comparison of Toxicity Scoring Systems for Radiation Pneumonitis: Impact on Risk Estimates among Patients with Non-small Cell Lung Cancer Z. X. Liao 1 , R. Komaki 1 , H. H. Liu 1 , Y. Chen 2 , M. Martel 1 , S. Wang 3 , H. Jin 4 , R. Mohan 1 , J. D. Cox 1 , S. L. Tucker 1 1 M. D. Anderson Cancer Center, Houston, TX, 2 University of Rochester Medical Center, Rochester, NY, 3 Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China, 4 Hunan Tumor Hospital and Institute, Changsha, Hunan, China Purpose/Objective(s): To compare the incidence of radiation pneumonitis (RP) scored using three different toxicity scoring sys- tems in a cohort of patients with non-small cell lung cancer (NSCLC) treated with definitive radiotherapy with or without chemo- therapy. Materials/Methods: The medical records, radiographic images, and radiation treatment plans were reviewed retrospectively at MD Anderson Cancer Center for 576 patients with NSCLC. The severity of RP was scored for each patient using each of three toxicity grading systems: the National Cancer Institute (NCI) Common Toxicity Criteria, version 2.0 (CTC2.0); the NCI Common Terminology Criteria for Adverse Events, version 3.0 (CTCAE3.0); and the grading system of the Radiation Therapy Oncology Group (RTOG). For each scoring system, and for each of four levels of toxicity (grade $ 1, $ 2, $ 3, and $ 4), two different risk models (Lyman and log-logistic) were fitted to data from the subset of patients having at least 6 months of follow-up after the end of...
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- Spring '10
- Speak, B. Research Grant, Radiation Pneumonitis, mean lung dose, toxicity scoring systems, Author Disclosure