L05-2010 - BioNB222 Cornell University Spring 2010 Joseph...

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BioNB222 Spring 2010 Cornell University Joseph Fetcho Lecture 05. Action Potential and Propagation II Reading Assignment Purves, D. , Augustine, G. J., Fitzpatrick, Hall, W.C. LaMantia, A.-S., McNamara, J.O. and White, L. E. (2008) Neuroscience. Sinauer Associates, Inc. Sunderland, Mass. Chapter 3. Learning Objectives: 1. To finish learning how the main features of the action potential, such as threshold, arise. 2. To learn how action potentials are propagated along axons and how the speed of this propagation can be increased. 3. To review the origin of all of the key features of action potentials. Lecture Outline 1. What is responsible for threshold? It is the point at which influx of sodium exceeds the efflux of potassium. At this point a positive feedback develops because the extra positivity inside from the sodium ions depolarizes the neuron more, which opens more sodium channels, which depolarizes the neuron more and opens more channels…
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BioNB222 Spring 2010 Cornell University Joseph Fetcho 2. The positive feedback loop also explains the all or nothing behavior of the action potential and the “overshoot” to positive potentials. The feedback
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This note was uploaded on 05/25/2010 for the course BIONB 2220 taught by Professor Hopkins,c.d. during the Spring '10 term at Cornell University (Engineering School).

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L05-2010 - BioNB222 Cornell University Spring 2010 Joseph...

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