L07-2010 - BioNB222 Cornell University Spring 2010 Joseph...

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BioNB222 Spring 2010 Cornell University Joseph Fetcho Lecture 07. Diseases of Ion Channels Reading Assignment Purves, D. , Augustine, G. J., Fitzpatrick, Hall, W.C. LaMantia, A.-S., McNamara, J.O. and White, L. E. (2008) Neuroscience. Sinauer Associates, Inc. Sunderland, Mass. Chapter 4. Learning Objectives: 1. To learn how the disruption of the function of ion channels leads to some neurological diseases. 2. To learn to appreciate the importance of having a good set of ion channels! Lecture Outline The importance of ion channels is revealed by the severe consequences of altering their normal function. In this lecture, we will explore some links between ion channel dysfunction and disease, with the emphasis on so-called channelopathies. 1. Remember from the beginning of my lectures that channels and ion flows are targeted by many animals to kill other animals. Classic examples of this include: A. Puffer fish and newts use tetrodotoxin, a sodium channel blocker, for defense, There are many such toxins – e.g. those used by cone snails to hunt prey.
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This note was uploaded on 05/25/2010 for the course BIONB 2220 taught by Professor Hopkins,c.d. during the Spring '10 term at Cornell University (Engineering School).

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L07-2010 - BioNB222 Cornell University Spring 2010 Joseph...

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