StudyQuestions_Week3 - Biology 180 Week 3 Study Questions...

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Biology 180 Week 3 Study Questions Spring 2010 Do these questions with your study group (~4 people). Follow these rules: Everyone must participate in every question that you work on. Listen to each person’s contributions. At least once during each study session, each group member should challenge another member’s ideas. Assign roles: If your group isn’t part of a large session at CLUE or Tribeta or the IC, one person should serve as timekeeper; one as organizer (keeping people on task and getting a consensus on when to move on to the next question for discussion); one as group-dynamics checker (making sure everyone is heard and respectful); one as challenger (making sure that all ideas are carefully considered). Format: 1. Each person should write answers to the first 5 questions on their own, in 30 minutes or less (these questions would be worth about 50 points on an exam). 2. Discuss each question (3 minutes each). 3. Exchange papers and use the answer key on p3 to grade each other for full credit, partial credit, or no credit (1 minute each). 4. Read through the rest of the question list. Each person should decide which question they want to work on most (meaning that they are LEAST confident about). 5. Go through the rest of the questions, taking turns to decide which to discuss next. 6. Each member of the group should write 2 exam questions, based on key concepts from this week, identified in your weekly notes summary. Use these questions to quiz each other. 1. Consider mutation. a. Explain why the following types of mutation are random. A change from a G to a C, when DNA is copied during chromosome replication. A change in chromosome number, due to an error in anaphase of meiosis I. b. Why could a change in the base sequence in the regulatory region of a gene change the phenotype? c. Mutation occurs at too low a frequency to be an important factor in changing allele frequencies in one generation. Why is mutation a more important evolutionary force in organisms with short generation times? Even in organisms with long generation times, why is mutation crucial to evolution?
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2. Consider alleles associated with human genetic disease. a. In each comparison below, circle the allele that would be eliminated FASTEST. In each case, assume that the phenotypic (disease) effects are equally severe. Circle both if no difference. Autosomal recessive v autosomal dominant X linked recessive v autosomal recessive Affects children vs affects 60 year olds Autosomal recessive: Some heterozygote advantage v no heterozygote advantage b. Most cases of thalassemia are caused by autosomal recessive alleles. A heterozygous woman marries an
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This note was uploaded on 05/26/2010 for the course BIO BIOL 180 taught by Professor Distilio during the Spring '09 term at University of Washington.

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StudyQuestions_Week3 - Biology 180 Week 3 Study Questions...

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