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BMI 211 01.28.10

BMI 211 01.28.10 - Effective Design in Clinical Informatics...

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Effective Design in Clinical Informatics BMI 211/CS 271 Amar Das Assistant Professor Medicine (Biomedical Informatics)
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Semantic Web Standards in Clinical Architectures
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Semantic Web Shared research and development plan to Provide explicit semantic meaning to data and knowledge shared on the Web Bring structure to Web content Advance the current state-of-the-art in Web information retrieval, which is keyword searching
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Semantic Web
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Semantic Web Shared research and development plan to Provide explicit semantic meaning to data and knowledge shared on the Web Bring structure to Web content Advance the current state-of-the-art in Web information retrieval, which is keyword searching Semantic Web applications will be able to process data and knowledge automatically through the use of ontologies
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Web 2.0
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Applications Translational Medicine Trials Management Scientific Discourse Bioinformatics Workflows Open Science
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Knowledge Application Knowledge Discovery Knowledge Asset Management HealthCare and Life Sciences: A Knowledge Driven Endeavor e.g., Application of clinical decision support rules e.g., Creation and maintenance of clinical decision support rules e.g., Analysis of clinical care transactions patient groups, biomarkers Slide courtesy of Vipul Kashyap
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Translational Medicine Improve communication between basic and clinical science Test theories emerging from preclinical experimentation on disease-affected human subjects Use preliminary human studies to refine our understanding of the biological principles underpinning the heterogeneity of human disease
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Current State 17 year innovation adoption curve from Biomedical Discovery Standard Practice Even if a clinical standard is accepted: 50% chance of receiving inappropriate care 5-10% chance of preventable, anticipatable adverse event Healthcare inflation leads to increasing resistance for reimbursement of new diagnostics and therapeutics
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Covell DG, Uman GC, Manning PR. Ann Intern Med. 1985 Oct;103(4):596-9 Current State 2 Million facts needed to practice Genomics and personalized medicine will increase the problem exponentially There are 3000+ molecular diagnostic tests on the market Typical drug order today with decision support accounts for, at best, Age, Weight, Height, Labs, Other Active Meds, Allergies, Diagnoses
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Current State Knowledge is usually “hardwired” into applications Little or no standardization on terminologies or information models Clinical systems implementations have inadequate knowledge to meet current workflow and quality needs Labor of converting knowledge into decision support is vastly underestimated Little support for versioning, provenance, change propagation of knowledge
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Clinical Case Clinical exam reveals abnormal heart sounds Family History: Father with sudden death at 40, 2 younger brothers apparently normal Ultrasound ordered based on clinical exam reveals cardiomyopathy Structured Physical Exam Structured Family History Structured Imaging Study Reports
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