CHEM151_Final 2009_Key

CHEM151_Final 2009_Key - 1. Match the following names with...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1. Match the following names with the appropriate structure : ginkgolide B, amphotericin B, rapamycin, brevetoxin B, Taxol , palytoxin, calicheamicin 1 I , epothilone B, vancomycin, resiniferatoxin (20 points) Name:_________________________________ Points:_________________________________________ Prof. K. C. Nicolaou Final Exam CHEM 151 - Molecules that Changed the World March 19, 2009 UCSD, Department of Chemistry and Biochemistry resiniferatoxin ginkoglide B epothilone B Taxol brevetoxin amphotericin B calicheamicin rapamycin vancomycin palytoxin 2. Match each of the following medicines with the appropriate molecular structure and mechanism of action : Nexium , AZT (Retrovir ), Valium , , Prozac (15 points) Molecular Structure Mechanism of Action A . Inhibits phosphodiesterase type5 (PDE5), an enzyme that cleaves and inactivates the messenger cyclic quanosine monophosphate (cQMP) B . Binds to GABA receptors C . Inhibits serotonin re-uptake, leading to higher levels of the neurotransmitter in the synapse D . Inhibits the HIV enzyme reverse transcriptase E . Blocks the H /K ATPase, an enzyme that pumps acid into the stomach Medical Indication I . antidepressant drug II . erectile dysfunction drug III . antianxiety drug IV . anti-ulcer drug V . anti-AIDS drug Nexium E IV Prozac C I AZT D V Valium B III A II 3. Name three (3) major pharmaceutical companies and two (2) successful biotechnology companies as well as fve (5) biologic drugs , indicating the medical indication for each (15 points). Major pharmaceutical companies: Biotechnology companies: 1. ____________________________________ 1._______________________________________________ 2. ____________________________________ 2....
View Full Document

This note was uploaded on 05/26/2010 for the course CHEM chem 151 taught by Professor K.c.nicolaou during the Winter '09 term at UCSD.

Page1 / 6

CHEM151_Final 2009_Key - 1. Match the following names with...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online